DNA Methylation Age Acceleration Research

Description

DNA Methylation Age Acceleration
Age acceleration can be defined as the difference between the DNA methylation age and the actual age, or as the residual resulting from regressing the DNA methylation age on the actual age. In comparison, the latter definition is more accurate and practical. We can determine the rate of biological aging based on the specific value of the DNA methylation age acceleration, with positive values indicating faster than expected aging and negative values the opposite.

DNA methylation age acceleration is closely related to the health status of the organism, aging-related diseases, mortality and other factors. On the one hand, several studies have identified DNA methylation age acceleration in age-related diseases, such as cancer, cardiovascular diseases, and neurodegenerative diseases. On the other hand, there are also some intrinsic and extrinsic factors that contribute to age acceleration in individuals, such as stress, alcohol consumption, smoking, etc.

Our Services
Our service focuses on studies that explore the specific relationship between biological age acceleration and various age-related realizations.

Genome-wide DNA methylation analysis

Genome-wide DNA methylation analysis

We perform genome-wide DNA methylation analysis, as well as data quality control, on blood samples or other tissue samples from large study populations.

Age acceleration calculation

Age acceleration calculation

we calculate the DNA methylation age acceleration by regression model and submit the processed DNA methylation data to obtain the age acceleration values.

Relevance statistical analysis

Relevance statistical analysis

We build multiple models to assess the relationship between DNA methylation age acceleration and various aging phenotypes such as health, disease, and death.

Our services address a wide range of studies, including studies of the association between age acceleration and some aging phenotypes, as well as studies of how various internal and external factors affect age acceleration.